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Could you explain what you mean by the 75 unique hand ranks? Can your 1326ish hands on the river usually be bucketed into 75 buckets where each bucket has the same equity or something?
Yes. 7 card hands can be given a number, the hand rank, between 1 and 7462 representing the strength of the hand, with 7462 being a royal straight flush. But for a given 5 card board there only 75 distinct hand ranks on average, and a maximum of about 140 as far as i know. On nut boards there is 1 distinct hand rank.
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The only issue I see with that is it wouldn't take into account card removal effects.
Well spotted. You might be able to ignore card removal effects when the distributions are not too uneven. When the distributions are very uneven there might be hands with effectively zero probability that could be pruned out. There might be ways to deal with card removal effects - I dunno, I haven't studied it for long. Card removal effects are expensive to model properly anyway.
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I think because in CFR+ negative cumulative regrets are reset to 0, they are able to do compression more easily because you can compress something like 0, 0, 0, 0, 0, 0, 0, 56, 54 to 7, 0, 1, 56, 1, 54, though I'm sure it's more sophisticated than that. I was thinking of using a form of CFR+, though I'm wondering how much compression/decompression will slow things down.
All agreed. There is often a trade-off between speed and memory. The paper talked about sorting boards too for more compression opportunities IIRC.